WebAN Tse et al. CHIR-124, a Novel Potent Inhibitor of Chk1, Potentiates the Cytotoxicity of Topoisomerase I Poisons In vitro and In vivo. Clin. Cancer Res. 2007, 13, 591-602. Y Tao et al. Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints. Cell Cycle. 2009, 8(8), 1196-205. JL Smith. WebCHIR124 is a potent and selective inhibitor of checkpoint kinase 1 (Chk1) ( IC50 = 0.3 nM) that produces G2-M abrogation which induces chemosensitisation. It also inhibits …
CHIR124 MedChemExpress Life Science Reagents
WebCHIR124 is a potent and selective inhibitor of checkpoint kinase 1 (Chk1) ( IC50 = 0.3 nM) that produces G2-M abrogation which induces chemosensitisation. It also inhibits PDGFR and FLT3 (IC50 = 6.6 nM and 5.8 nM respectively). CHIR-124 inhibits Pgp activity in multidrug-resistant cell lines KB-V1 and A2780-Pac-Res. Safety Information 保管分類 … WebFeb 1, 2007 · CHIR-124 is a quinolone-based small molecule that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC (50) = 0.0003 micromol/L). cindy charnay
Submitted 4/6/2024 4:24:19 PM Filing ID: 124864 Accepted …
WebCHIR-124 (200 nM) leads to a 2.5-fold elevated level of cdc25A above that of the untreated HCT116 p53−/− cells. The down-regulation of cdc25A induced by SN-38 is completely restored by concurrent or sequential treatment with CHIR-124, proving that CHIR-124 inhibits the Chk1-mediated destruction of cdc25A in whole cells[1]. CHIR-124 occupies ... WebCHIR-124 is a potent inhibitor of checkpoint kinase 1 (Chk1) with an IC 50 value of 0.3 nM. Chk1 is an ATP-dependent serine-threonine kinase that is very important to the … Web2. Please refer to Response to CHIR No. 1, question 2. The Postal Service states that it “performed qualitative market research focused on Small and Medium Business (SMB) shippers who the Postal Service identified as a core target market of this product” by interviewing twelve interviewees. Response to CHIR No. 1, question 2.a. diabetes medicine and pancreatitis