Cyp17a1蛋白
Webcyp17a1蛋白属于细胞色素p450氧化酶超家族的一员，定位于内质网，既有甾体的17α-羟化酶也有17,20-裂合酶活性，在类固醇生成途径中将孕烯醇酮或孕酮的d环上17号c原子上α … CYP17A1 is a 57.4 kDa protein that belongs to the cytochrome P450 family. The protein encoded by its cDNA is composed of 508 amino acid residues. As an enzyme, CYP17A1 possesses an active site that associates with a heme prosthetic group to catalyze biosynthetic reactions. See more Cytochrome P450 17A1 (steroid 17α-monooxygenase, 17α-hydroxylase, 17-alpha-hydroxylase, 17,20-lyase, 17,20-desmolase) is an enzyme of the hydroxylase type that in humans is encoded by the … See more Gene The CYP17A1 gene resides on chromosome 10 at the band 10q24.3 and contains 8 exons. The cDNA of this gene spans a length of 1527 bp. This gene encodes a member of the cytochrome P450 superfamily … See more CYP17A1 is a member of the cytochrome P450 superfamily of enzymes localized in the endoplasmic reticulum. Proteins in this family are monooxygenases that catalyze synthesis of cholesterol, steroids and other lipids and are involved in drug metabolism. CYP17A1 has both … See more • Pregnenolone • 17α-Hydroxypregnenolone • Progesterone • 17α-Hydroxyprogesterone See more Expression of CYP17A1 has been found in all of the traditional steroidogenic tissues except the placenta, including the zona reticularis and zona fasciculata of the adrenal cortex, the Leydig cells of the testes, the thecal cells of the ovaries, and, more recently, in See more Mutations in this gene are associated with rare forms of congenital adrenal hyperplasia, specifically 17α-hydroxylase deficiency/17,20-lyase deficiency and isolated 17,20-lyase deficiency See more CYP17A1 inhibitors Currently, the FDA has approved only one CYP17A1 inhibitor, abiraterone, which contains a steroidal … See more
Cyp17a1蛋白
Did you know?
http://www.jinpanmed.cn/archives/date/2024/04/11 WebJan 22, 2012 · Cytochrome P450 17A1 (also known as CYP17A1 and cytochrome P450c17) catalyses the biosynthesis of androgens in humans. As prostate cancer cells proliferate …
WebMar 21, 2024 · CYP11A1 (Cytochrome P450 Family 11 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP11A1 include Adrenal Insufficiency, Congenital, With 46,Xy Sex Reversal, … WebFeb 22, 2024 · CYP17A1 ；, CPT7, CYP17, P450C17, S17AH, cytochrome P450 family 17 subfamily A member 1 外部ID OMIM ： 609300 MGI ： 88586 HomoloGene ： 73875 GeneCards ： CYP17A1
细胞色素 P450 17A1（英語：Cytochrome P450 17A1）也被称为甾体17α-单加氧酶（steroid 17α-monooxygenase），17α-羟基化酶（17α-hydroxylase），17,20-碳链裂解酶（17,20-lyase 或 17,20-desmolase）是一种羟基化酶，由位于人类10号染色体的 CYP17A1 基因编码 。这一基因在许多组织与细胞中都有表达，特别是肾上腺皮质的网状带（英语：zona reticularis）和 …
WebFeb 22, 2024 · 结构 [] 基因 []. CYP17A1 基因位于10号染色体的10q24.3带上包含有8个外显子 ，其cDNA全长为1527bp。. 蛋白 []. CYP17A1蛋白大小为57.4kDa ，包含有508个氨基酸残基，属于CYP450超家族 ，带有一个血红素相关活性位点以催化相关生物反应 。. CYP17A1可被两种甾类抑制剂 阿比特龙 （ 英语 ： abiraterone ） 和galeterone特异 ...
WebCYP17A1. （cytochrome P450 family 17 subfamily A member 1）. 该基因编码细胞色素p450酶超家族的一个成员。. 细胞色素p450蛋白是一种单加氧酶，催化药物代谢和胆固 … softube pluginWeb说明书. CYP17A1 抗体 D-12 是小鼠单克隆 IgG 2a κ， CYP17A1抗体, 在 12篇文献中引用 ，规格为 200 µg/ml. 免疫原氨基酸序列461-508位于human物种的CYP17A1的C … softube optoWebThe CYP17A1 gene provides instructions for making a member of the cytochrome P450 enzyme family. Like other cytochrome P450 enzymes, CYP17A1 is involved in the formation (synthesis) of steroid hormones. This group of hormones includes sex hormones such as testosterone and estrogen, which are needed for normal sexual development and … slow cooker wild rice casseroleWebCYP17A1 也称细胞色素 P450C17，它是一种属于 P450 细胞色素单氧酶超家族的类固醇激素合成酶 (1, 2)。. 在人体中，CYP17A1 在肾上腺皮质 … slow cooker wild rice chicken soupWebCytochrome P450 17A1 (CYP17A1; also P450c17and P450sccII) is a critically important enzyme in humans that catalyzes the formation of all endogenous androgens. It is an atypical cytochrome P450 enzyme in that it catalyzes two distinct types of substrate oxidation. Through its hydroxylase activity, it … softube marshall amp simWebCYP21A2蛋白；细胞色素P450家族成员21B (CYP21A2)重组蛋白两个建议：. 1、用非变性纯化样品去做EK酶切、纯化。. 如果融合蛋白的降解是从N端开始的，而C端没有降解，那么应该能够拿到38肽。. 我曾经有个这么个类似情况，酶切后证实是N端降解，C端的目的蛋白好 … softube plugins crackWeb进一步实验证实CPSF6是通过APA调节作用于下游靶点基因人宫颈癌癌基因2(HCCR2)，使其具有缩短3'UTR的转录本高表达，翻译更多的蛋白，进而调节肝癌的增殖和转移过程。另外，实验中发现let-7a、let-7c、miR-26a三种miRNA结合在CPSF6基因3'UTR上直接抑制基因的 … softube plugins free download tore