Dynamo mapping vector field of single cells
WebFeb 2, 2024 · Our analytical framework, dynamo, consists of four integral stages: 1) estimation of genome-wide kinetic rate constants and velocity vectors, 2) reconstruction of single-cell vector field functions with the resultant cell state and velocity samples, 3) in-depth analyses leveraging various differential geometry analyses, and 4) predictions of ...
Dynamo mapping vector field of single cells
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WebFeb 17, 2024 · In this work, we introduced dynamical systems theory and differential geometry analyses to single-cell genomics. A dynamical system describes the time … WebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these data, howev
WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - GitHub - KBRI-Biology-Experiment-Comput... WebFeb 1, 2024 · Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - dynamo-release-Mapping-Vector-Field-of-... WebHome: Cell Press
Web•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell (sc)RNA-seq, together with RNA velocity and metabolic labeling, reveals cellular states and transitions at unprecedented resolution.
WebInclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction and differential geometry analyses - dynamo-release-Mapping-Vector-Field-of-... during the neolithic revolutionWebAug 8, 2024 · In large datasets, it is easier to visualize the prevalent pattern of cell velocities with locally averaged vector fields (Fig. 2i). Because cells can have RNA velocities along multiple ... cryptocurrency medium of exchangeWebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector field reconstruction, potential landscape mapping, … during the neolithic period art went fromWebLeveraging the least-action-path method, dynamo accurately predicts drivers of numerous hematopoietic transitions. Finally, in silico perturbations predict cell-fate diversions induced by gene perturbations. Dynamo, thus, represents an important step in advancing quantitative and predictive theories of cell-state transitions. during the nineteenth century toeflWeb•Vector fields reveal the timing and mechanisms of human hematopoiesis •Dynamo allows cell-state transition path and in silico perturbation predictions . Summary. Single-cell … during the night of the present dayWebJul 9, 2024 · Here, we introduce dynamo , an analytical framework that reconciles intrinsic splicing and labeling kinetics to estimate absolute RNA velocities, reconstructs velocity vector fields that predict future cell fates, and finally employs differential geometry analyses to elucidate the underlying regulatory networks. cryptocurrency meaning in chineseWebDynamo: Mapping Transcriptomic Vector Fields of Single Cells. Inclusive model of expression dynamics with metabolic labeling based scRNA-seq / multiomics, vector … during the new deal american blacks