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WebMay 13, 2024 · Repair of epithelial tissues such as the lungs is essential for restoring organ and barrier function after infection or disease. Lucas et al. demonstrate that damaged … WebAug 2, 2024 · Pten flox/flox mice can be born with normal PTEN expression levels (Lesche et al. 2002; Groszer et al. 2001). To verify Cre recombinase-induced deletion of Pten exon 5, they crossed Pten -floxed females with males carrying a nestin promoter-driven Cre transgene which is activated in central nervous system stem/progenitor cells at …
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WebFor this, we used an inducible luminal lineage-specific mouse model, where Pten deletion is induced in Keratin8 (K8 +) luminal cells (K8-Cre ERT2;Pten Flox/Flox;Rosa26-Stop Flox/Flox-EYFP, hereafter K8PY mice), as well as age-matched Pten-competent mice as controls (K8-Cre ERT2;Rosa26-Stop Flox/Flox-EYFP; hereafter K8Y mice) (Figure 1 A).
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