Webb12 jan. 2024 · Anti-citrullinated protein antibodies (ACPAs) are autoantibodies against citrullinated peptides and proteins. The specificity of anti-cyclic citrullinated peptides … Webb6 feb. 2024 · Citrullination was defined as a +0.984016-Da mass shift at arginine residue. In the cells expressing wild-type PAD4, 171 of 3,457 proteins (4.95%) were citrullinated, …

Citrullination of RGG Motifs in FET Proteins by PAD4 …

Webb23 jan. 2024 · Citrullination of proteins is a new kind of post-translational modification, which has been reported to be involved in large numbers of autoimmune diseases and … Webb22 dec. 2024 · Citrullination is a historically less explored, yet increasingly studied, protein PTM which has profound effects on protein conformation and protein-protein interactions. Dysregulation of protein citrullination has been associated with … chicco baby moments soft cleansing wipes

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Webb1 jan. 2005 · Citrullinated proteins that are produced by enzymatic deimination of arginine residues in proteins by peptidylarginine deiminases (PADIs) are of particular interest in … Webb8 sep. 2024 · Increased protein citrullination (PC) and dysregulated protein arginine deiminase (PAD) activity have been observed in several neurodegenerative diseases. PC is a posttranslational modification catalyzed by the PADs. PC converts peptidyl-arginine to … Webb3 aug. 2009 · Citrullination is catalyzed by PADs dependent on a high calcium concentration. Five PAD isoforms (PAD1, PAD2, PAD3, PAD4 = 5, PAD6) are currently distinguished. Proteins lose specific positive charges through deimination (arginine → citrulline) and can change conformation, becoming more susceptible for degradation . google internship for first year students